Showing posts with label Oseltamivir. Show all posts
Showing posts with label Oseltamivir. Show all posts

Friday, August 7, 2009

The trouble with Tamiflu

OseltamivirImage via Wikipedia

Not the latest news, but not a week old yet, so it is still timely. For those who haven't read about this news, it is a priceless piece of info, so we don't just administer the medicine to our kids…
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Flu drug 'linked to side effects among children': Reports

THE DAILY TELEGRAPH

Recent studies have led to growing concern about Tamiflu's side effects on children.

MORE than half of the children taking Tamiflu to combat H1N1 flu suffer side effects such as nausea, insomnia and nightmares, new research claims.

The anti-viral drug, which is being handed out to hundreds of thousands of Britons, can also produce stomach pains, vomiting and diarrhoea, research suggests.

A study found that almost one in five youngsters experience neuropsychiatric side effects, such as poor concentration, confusion, and sleeping problems.

Thousands of schoolchildren were given the drug as a preventive measure during the early stages of the H1N1 flu pandemic in Britain.

The findings are likely to lead to concern among parents that their children's performance at school has been jeopardised by taking the drug.

Only people with suspected or confirmed H1N1 flu are now being prescribed Tamiflu.

Two studies from experts at the Health Protection Agency (HPA) showed a "high proportion" of British schoolchildren reporting problems after taking Tamiflu.

Data was gathered from children at three schools in London and one in south-west England who were given Tamiflu earlier this year after classmates became infected.

One study, of 248 children aged 11 and 12 at a school in south-west England, which was closed after a pupil contracted the virus, found that more than half suffered side effects from taking Tamiflu.

The researchers said "likely side-effects were common" and the "burden of side effects needs to be considered" when deciding on giving Tamiflu to children prophylactically.

Another study of 103 schoolchildren found that 45 suffered side effects such as nausea, stomach pain, problems sleeping, vomiting and diarrhoea.

Almost one in five (18 per cent) reported a neuropsychiatric side effect, such as poor concentration, inability to think clearly, problems sleeping, feeling dazed or confused and nightmares.

The report concluded: "This may be of particular concern to exam-year students (and their parents)."

The studies were carried out in the early stages of the pandemic, when everyone sharing a classroom with a child who had developed the H1N1 flu was given the drug, even if they did not show any symptoms.

The findings were disclosed as it emerged that the Japanese authorities are advising doctors not to prescribe Tamiflu to youngsters between the ages of 10 and 19 over fears of neuropsychiatric side effects.

A statement from Roche, which manufactures Tamiflu, said the contribution of Tamiflu to neuropsychiatric effects "has not been established".

A spokeswoman for Britain's Department of Health said: "As is the case with many medicines, nausea is a known side effect of Tamiflu, in a small number of cases.

"Symptoms may lessen over the course of the treatment, and it may help to take Tamiflu either with or immediately after food, and drinking some of water may also lessen any feeling of nausea."

From TODAY, News – Weekend, 01-Aug-2009

Thursday, July 30, 2009

Expectant women more at risk?

A pregnant woman
A pregnant woman (Photo credit: Wikipedia)

LONDON - Pregnant women who get Influenza A (H1N1) are at least four times as likely to be hospitalised as other people with the virus, a new study says.

While experts do not know if pregnant women are more susceptible to getting H1N1, they say that once pregnant women are infected, they have a higher risk of complications.

Researchers at the United States Centres for Disease Control and Prevention (CDC) analysed the first 34 US cases, including six deaths, of H1N1 in pregnant women from April to mid-June.

They concluded that expectant women suspected of having H1N1 should be given Tamiflu as soon as possible, even before tests confirm the diagnosis.

The experts also recommended that they should be among the first in line when a vaccine is ready.

The study was published online yesterday in the medical journal Lancet.

Lead researcher Denise Jamieson from the US CDC, said the agency does not recommend any special precautions for pregnant women to avoid catching the flu virus.

But if they do catch the virus, doctors need to act fast, preferably within 48 hours of developing symptoms.

Of the six fatal cases in the Lancet study, nearly all had viral pneumonia before experiencing acute respiratory problems, and were put on ventilators before they died.

Aside from one woman who had asthma and another who was obese, the pregnant women were essentially healthy, said Ms Jamieson. AP
 

From TODAY, World – Thursday, 30-Jul-2009

Sunday, July 5, 2009

A third resistant case

OseltamivirImage via Wikipedia
Detected in Hong Kong; other cases in Denmark and Japan 

HONG KONG - Hong Kong on Friday detected a strain of H1N1 that was resistant to Tamiflu, the health department reported on its website, during routine tests of its sensitivity to anti-virals.

The case came as the Japanese health ministry said doctors had detected the second case worldwide of a patient resistant to Tamiflu.

In the Hong Kong case, the resistant virus was isolated from a specimen taken from a 16-year-old girl who arrived in the southern Chinese city from San Francisco last month. But the strain is not resistant to the other anti-viral drug, Relenza, the health department said.

A spokeswoman for Swiss pharmaceuticals giant Roche, which makes Tamiflu, said the company had been informed of the case and called it "normal". She said "0.4 per cent of adults develop resistance" to Tamiflu.

In Japan, the health ministry said doctors in Osaka prefecture had identified a woman who was resistant to Tamiflu - the second such case, after one found in Denmark. The Japanese woman had since been treated with Relenza and was recovering, Kyodo news agency reported Thursday.

In Washington, the White House is set to hold a high-level meeting next week to prepare for the possibility of a more severe H1N1 flu outbreak.

The US Centers for Disease Control and Prevention said last week at least 1 million people in America have had the flu, taking into account many cases gone unreported to the authorities. There have been about 287,000 confirmed cases and 127 deaths.

World Health Organization Director-General Dr Margaret Chan and the world's health ministers met on Thursday in Mexico for a two-day summit to devise strategies amid fresh concern over the pandemic's spread. The flu is running wild in the southern hemisphere and is spreading rapidly through Europe.

Argentina has seen a sharp rise in fatalities, with the number of dead rising from 26 to 43 within five days. Argentina has surpassed Canada as the country with the most H1N1-linked deaths after the US and Mexico. AGENCIES

From TODAY, World – Saturday, 04-Jul-2009